Natural disasters are becoming increasingly frequent in regions throughout the United States. This study performed by researchers at Binghamton University focuses on how to prepare pharmaceutical supply chains for the effects of natural disasters. During natural disasters, access to medication is critical. This study develops an inventory control model through the application of mathematical programming techniques to provide methods for natural disaster preparation. The methods developed are focused on helping pharmaceutical supply chains to have a high rate of resilience following disasters. Through the consideration of multiple variables, the authors were able to minimize inventory cost while accounting for the optimal safety stock and refill quantity in case of a natural disaster.